How fast does miralax work

How fast does miralax work,  MiraLax is the brand name for the generic drug polyethylene glycol 3350, a laxative used to treat occasional constipation.

The drug works by bringing water to the intestines, which helps keep the digestive system regular. Fecal matter becomes milder when the intestines retain water.

How fast does miralax work

MiraLax usually relieves constipation in one to three days.

Braintree Laboratories first introduced MiraLax in 1999, and was available prescription only until 2006, when the Food and Drug Administration (FDA) concluded that polyethylene glycol 3350 was safe and effective, and could be sold without a prescription (OTC) rather than by prescription.

In 2009, the FDA approved additional generic forms of polyethylene glycol 3350 DA, marketed under the name Polyethylene glycol 3350 or PEG 3350.

A study published in the American Journal of Gastroenterology in 2013 reported that polyethylene glycol 3350 plus electrolytes was an effective treatment for constipation in adults with a particular type of irritable bowel syndrome with constipation (sometimes IBS-C).

IBS-C is a gastrointestinal disorder that causes pain or discomfort due to changes in the frequency or consistency of bowel movements.

That year, Schering-Plough Corporation signed a licensing agreement with Braintree to market MiraLax without a prescription as a treatment for casual constipation, and the FDA granted Schering-Plough three years of exclusivity for the OTC drug.

Some pediatricians have expressed concern that MiraLax is routinely given to children for extended periods, although it has never been approved by the FDA for children under 17 years of age, and the long-term effects of use in children have not been studied.

A 2009 meeting of the FDA’s Drug Safety Oversight Board discussed reports of metabolic acidosis (high levels of acid in the blood) and psychiatric events including seizures, tremors and aggressive behaviors among children use polyethylene glycol laxatives like MiraLax.

MiraLax Warnings

Do not take MiraLax if you have kidney disease or a polyethylene glycol allergy.

Polyethylene glycol 3350 can create habit. If you use MiraLax too often or for an extended period of time, it can become laxative-dependent.

Using it often and for a long time could also result in an electrolyte imbalance.

People who have or may have a bowel obstruction (blockage in the intestine) should not take MiraLax. Have your doctor rule out this condition before using MiraLax.

Symptoms of an intestinal obstruction include nausea, vomiting, severe stomach and belly pain.

Before taking MiraLax, be sure to speak with your doctor if you have any of the following:

  • Nausea or vomiting
  • Abdominal pain
  • A sudden change in bowel habits that lasts more than two weeks
  • Irritable bowel syndrome (SII)

Your doctor should also know if you have or have had a bowel obstruction or if you have symptoms of intestinal obstruction, such as upset stomach, vomiting and stomach pain.

It is also important to speak with your doctor before using MiraLax if you are pregnant, pregnant or breastfeeding.

If you experience rectal bleeding, nausea or progressively worsening abdominal pain, or if your constipation does not improve after taking MiraLax for a week, talk to your doctor right away. These could be signs of a more serious condition.

Children under the age of 17 should take MiraLax only under the supervision of their pediatrician.

Frequently Asked Questions

Q: I’m taking generic MiraLax. Does it affect the absorption of any other drugs you are in? And when should you take it? I am taking several medications, and the last, which is propranolol, is taken around 11 p.m. Then I’ll wait half an hour to take the MiraLax or vice versa. Does it affect what you do?
A: Combining MiraLax (polyethylene glycol) with propranolol (Inderal), no significant interactions were found for these selected drugs. Caution is always advised with multiple medications. Therefore, MiraLax does not seem to affect the absorption of propranolol and should not matter when taking one. Talk to your health care provider before making any changes to prescription medications. Lowell Sterler, RPh

Q: My 3 1/2 year old granddaughter has been in Miralax since I was 9 months old. I worry that she may have health problems later on because this chemical is in her body for so long. Can you tell me if this is okay?

A: Miralax (polyethylene glycol) is an osmotic laxative used to treat constipation. Miralax works by bringing water into your stool, which softens stool and helps it pass. Miralax is approved by the U.S. Food and Drug Administration (FDA) for occasional constipation. According to the package information, Miralax should be used for two weeks or less or as directed by a doctor. Prolonged use of Miralax has the potential to cause electrolyte abnormalities and/or laxative dependence (not being able to evacuate without laxative). Consult your pediatrician to discuss the risks and benefits of long-term use of Miralax. Miralax should be dissolved in 8 ounces of water or juice before taking it. Tell your child’s doctor if you have cramps, if constipation gets worse, or if there is swelling, nausea or diarrhea. Some ways to help prevent constipation include drinking lots of fluids, eating a high-fiber diet, and exercising a lot. Fiber is found in fruits, vegetables, whole grains and beans. It is important to discuss the side effects of your medicines with your doctor. For more specific information, consult your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD

Q: Can you tell me if Miralax laxative and similar generics are a natural laxative or one that will become habit?

A: Miralax is a laxative composed of the active ingredient polyethylene glycol 3350 (PEG) and has been studied and tested as safe and effective in more high quality clinical trials than any other laxative. It’s not considered a natural laxative, but that doesn’t make it a bad thing either. PEG is used in a variety of different forms in many medications, such as laxatives, intestinal preparations used for colonoscopy, IV medications, and skin creams. It has an extremely low risk of toxicity and can be used for extended periods of time without the risk of becoming a psychological or physical habit. Here is some information about the Miralax product that may be able to answer some of your questions: Lori Poulin, PharmD

Q: Is there any interaction between Miralax and lisinopril, Zocor, Plavix, aspirin or HCTZ?

A: Although there are some interactions between several of the drugs you currently use, such as Plavix and aspirin, or lisinopril and hydrochlorothiazide, these drugs are often prescribed together because the benefits outweigh the risks. The only precaution with the addition of Miralax (polyethylene glycol 3350) to your drug regimen is that chronic use of Miralax and hydrochlorothiazide can cause significant loss of fluids and electrolytes, including sodium, potassium, magnesium and zinc. In general, laxatives should only be used in the short term at recommended dosages under the supervision of your doctor. When using Miralax with hydrochlorothiazide, be sure to contact your doctor if you experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urine, fainting on the way, or a rapid heart rate. A more natural way to promote intestinal regularity is regular exercise and a high-fiber diet. You may also consider using a breast-forming laxative instead if you need relief for long-term constipation.

Q: A specialist I saw a couple of years ago told me to take 1 cup of CoLyte when my symptoms of IBS constipation started acting. Need a prescription for it? Or is there something similar to buy over the counter?

A: The active ingredient in Colyte is PEG 3350. This is the same ingredient found in Miralax, now over-the-counter. You can also find useful information about Miralax at. Matt Curley, PharmD

Q: Can I take Miralax daily?

A: Miralax (Polyethylene Glycol 3350) is a laxative that increases the amount of water in the intestines. Miralax is used to treat occasional constipation and irregular bowel movements. Measure the dose of Miralax with the medicine cap in the bottle. This cap should contain dose marks on the inside of it. Pour the powder into 4 to 8 ounces of a cold or hot liquid such as water, juice, soda, coffee or tea and use as prescribed. Miralax may produce bowel movements within 1-3 days of the initial dose. Do not use Miralax for more than 7 days without consulting your doctor. Call your doctor if you are still constipated or irregular after using this medicine for 7 days at a time. Frequent or excessive use without doctor’s approval can alter the body’s chemical balance and lead to laxative dependence. Common side effects of Miralax may include bloating and gas, upset stomach and dizziness. Miralax can cause loose or watery bowel movements. Some medications may interact with Miralax. Tell your doctor about all prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and medications prescribed by other doctors. Do not start using a new medicine without telling your doctor. Miralax is available as a prescription or over-the-counter. Call your doctor if you think you need to use Miralax daily. Your health care provider can provide guidance based on your health status and medications. Kimberly Hotz, PharmD

Q: Is it OK to use Miralax for my 8-month-old baby?

A: Miralax (polyethylene glycol [PEG]) is not indicated or studied in children under 18 months of age. It is not recommended to give this to infants or children under 17 years of age. If your child has a history of occasional or chronic constipation, it’s best to see a doctor. I have provided a link on constipation in children that may be helpful. . Lori Mendoza, PharmD

Q: Why has Miralax been withdrawn from the market?

A: Some of MiraLAX’s over-the-counter products have been withdrawn from the market. Schering-Plough’s retreat is for 17.9 oz bottle and 19.9 oz bottle. The caps of these bottles may not fit correctly. There are concerns that this may pose a choking risk to children, as well as allow contamination of the bottle contents. If you are using or have used MiraLAX, do not be alarmed; there are no reported problems with the actual medication. Many generic forms of MiraLAX bottles are still available and MiraLAX packages have not been removed. Burton Dunaway, PharmD





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