Juvenile diabetes research foundation..JDRF (formerly known as the Juvenile Diabetes Research Foundation) is a 501 charitable major (c) (3) organization dedicated to the funding of type 1 diabetes (T1D) research. The stated mission of the JDRF is “to improve the lives of all people affected by T1D by accelerating progress on the most promising opportunities to cure, better treatment and T1D prevention.”
juvenile diabetes research foundation
JDRF has directed a total of $ 1.6 billion to investigate since 1970, $ 116 million of it in FY2011. JDRF uses more than 80% of its expenses to support research and education related to research. ”
The organization has its Executive Office in New York City, with Chapters and Branches throughout the United States and international affiliates in Australia, Canada, Denmark, Germany, Israel, Mexico, the Netherlands and the United Kingdom.
History and foundation
JDRF was founded in the Philadelphia area. Led by the Duchy of Leeward, a group of local parents of children with T1D mobilized to raise money for diabetes research and formed the first Chapter of what was then known as the Juvenile Diabetes Foundation. A second Chapter was founded shortly thereafter in Miami, Florida, followed by Chapters in New Jersey to the north and Washington, DC
The new organization was defined by its commitment to research funding. In addition to the high priority in funding the T1D investigation, the founders of the organization resolved to inform the public about all aspects of T1D, advocate for more research funding from the federal government, and maintain the organization system of the address by legos of the volunteer.
Since its inception, JDRF has evolved to become a world leader in the fight against T1D. JDRF now has Chapters and Branches in most US states and international affiliates in several different countries.
Fundraising and defense
The largest fundraising event of the JDRF in the United States is the Diabetes Cure Walk. It is believed that across the country events raise awareness about type 1 diabetes and seek funds to move towards research.
The JDRF Children’s Congress is their first defense event and is held every two years in Washington, DC Children ranging from age 4 to 17 are selected from each state to become the delegate of their state in Washington. Delegates then head to Washington to meet with their representatives to tell their stories and advocate for increased federal funds and support for type 1 diabetes research.
JDRF funds research that aims to improve the lives of people with type 1 diabetes today and in the future. JDRF focuses on the research it seeks: stop or slow the progression of the disease in people who are newly diagnosed; invest the disease and its complications in those who have lived with it for years;
prevent type 1 in people in danger and in future generations; and improve treatments for type 1 diabetes and provide better tools to achieve tight blood glucose control for people at all stages of the disease.
About the causes
Even today there are many unanswered questions in the area of diabetes study. The line of research of greatest scientific interest is to find answers mainly to two questions: what causes diabetes and how it is triggered. On the other hand, and once the cause is known, can you find a way to cure it? This is the great challenge.
As we advance in the knowledge of the causes, it becomes clear that there are several factors that originate it and that it behaves and evolves differently according to the cases, so that scientists have begun to talk about the existence of several diabetes .
In type 1 diabetes, it seems that pancreatic beta cells (those responsible for the manufacture of insulin ) have an important inflammation, which leads the immune system to create a type of antibodies that are responsible for destroying these cells. The aforementioned antibodies can be found in the blood even years before diabetes is openly declared. Do these antibodies (anti-beta cells or anti- insulin ) have a predictive value?
According to the studies carried out so far, there is also a close relationship between some genes, which code the compatibility between tissues. It is a high-risk association to have a certain genetic pattern together with certain antibodies. We are thus facing another big question: to have a certain type of genes, can predispose to develop antibodies?
In different countries there is a different incidence of Type 1 diabetes depending on race, climate, diet, geographical latitude, … which suggests that there may be unidentified environmental factors that act as predisposing factors.
Type 1 Diabetes. Trigger? Virus? Toxic? Autoimmunity? Predisposition? Environmental factors? Which? Feeding? Weather? Lifestyle?
In Type 2 Diabetes, on the contrary, it has been found that all individuals, to a greater or lesser degree, have an insulin resistance . It should be noted that, despite the fact that insulin resistance is common in all cases, by itself it is not enough to develop Type 2 diabetes, since it requires the existence of other elements, which can be highly variable (environmental and genetic) and that amplify or modulate. There are cases, for example, of obese people who, even having insulin resistance , do not develop diabetes.
In Type 2 Diabetes an important genetic basis is recognized and, in many cases, with a dominant hereditary pattern.
Most studies have shown that these genes are involved in both a partial defect of pancreatic beta cells that produce poor quality insulin and a defect in insulin receptors located in all cells and tissues of the body.
Obesity (especially with an abdominal distribution of fat), decreased muscle activity, aging of the population and other factors related to lifestyle and diet are closely related to Type 2 diabetes and its evolution natural.
Type 2 diabetes
Are some genes responsible for the body’s cells being less sensitive to the hypoglycaemic action of insulin ?
How and in what way do they affect?
Are we facing a defect in the beta cells of the pancreas that influences, not in the quantity, but in the quality of the insulin they make?
Alteration of several genes and, in addition, environmental influence?
Is it a combination of all the above causes?
About drug treatment
The discovery of insulin (1922) and its availability for use in humans has undoubtedly been the greatest advance of the twentieth century and the entire history of diabetology. From that moment his natural trajectory was modified and stopped being a disease of rapid evolution with the result of death.
Over the last 60 years (very little time compared to the history of medicine), many achievements have been made thanks to biomedical discoveries, pharmacology and technological advances.
A good example of this are:
The antibiotics and serums that have allowed to treat intercurrent diseases avoiding decompensations and reducing risks.
Oral antidiabetics that act by improving the peripheral sensitivity to insulin , facilitating the production of insulin by the beta cells of the pancreas , slowing the absorption of glucose in the intestine or favoring its elimination by the urinary tract.
The possibility of treating other related diseases, such as obesity, hypertension, dyslipidemia …
Forms of treatment
Use of two or more combination drugs, for example, insulin plus oral antidiabetics; different types of insulin …
Intensive treatments with multiple doses of insulin or with continuous insulin infusion pumps .
Laser photocoagulation in diabetic retinopathy .
Transplants of kidney and pancreas , or of beta cells.
Incorporation of health education into healthcare practice.
Easy determination of glucosuria and ketonuria .
Determination of blood glucose and capillary ketonemia.