Metformin acne.. The evidence that has been collected about hyperinsulinism ( insulin resistance ) as the main cause of acne coincides with the results of studies showing that the drug Metformin (Glucofage) is superior to contraceptive pills and Roacutane for the treatment of acne .
How does hyperinsulinism (insulin resistance) cause acne?
Those who consume excess carbohydrates in their diet cause an increase in insulin that causes acne in two ways:
In women Insulin stimulates in the ovaries the exaggerated production of male hormones. These women with excess Testosterone have male symptoms such as: androgenous alopecia (hair loss of greasy root), hirsutism (excess hair), increased fat in the abdomen, acne and sometimes even higher incidence of bi-sexuality.
In men and women, insulin directly stimulates the gland, causing acne
What is the treatment of acne?
The medicine Roacutane and especially the contraceptive pills (including Diane 35) worsen hyperinsulinism (insulin resistance) and although they initially reduce acne, by inhibiting the ovary, this is only temporarily because when the treatment is finished the insulin stimulates again in the Ovarian production in excess of the male hormone (Testosterone) causing acne.
The most important treatment to really cure the cause of acne is to follow a healthy lifestyle like Ni One Diet More to improve the action of insulin.
In many cases, just carrying the lifestyle Ni One Diet More is enough for acne and the other symptoms of hyperinsulinism to disappear completely.
The drug Metformin (Glucofage) has also proven to be very useful as a treatment for acne without the side effects of birth control pills. Sometimes in women with very severe acne cases in addition to the Ni Diet One More Lifestyle and the drug Metformin (Glucofage) it is necessary to temporarily take a medication to lower male hormones.
Antiadrogenic Drugs : Medicines to decrease Testosterone
Flutamide (Etaconil, Eulexin)
Cyproterone acetate (Androcur)
Finasteride (Proscar, Propecia, Fincar, Finpecia, Finax, Finast, Finara, Finish, Prosteride, Gefina, Appecia, Finasterid IVAX, Finasterid, Alternova)
Spironolactone (Aldactone) is a diuretic but with action against Testosterone.
The use of antiandrogens is very delicate and should always be taken under strict medical supervision.
Antiandrogen drugs affect the development of the fetus when they are used during pregnancy so they should never be taken by women with any chance of becoming pregnant. It is important to know that many women have unplanned pregnancies and they only know about pregnancy 4-8 weeks after onset.
How has the treatment of acne changed?
What happens in women with hyperinsulinism (insulin resistance) who take birth control pills?
I’m Margarita Jimenez, I have two twin daughters who are 19 years old. Since the 15 have been very chubby but until 1 year ago was that the endocrine diagnosed insulin resistance. In both cases the diet and the treatment was the same: Metformin (Glucofage) of 500 mg in the morning and in the evening and the diet high in proteins that complemented it with the merengadas, the one of chocolate that they adore.
Both had the same problem, protruding belly, oily hair, vellitos in the face and much but much acne. I realized I had two very depressed daughters with low self-esteem because besides being gorditas (this limited their outings and clothing and group of friends), they also had a very severe acne that ended up finishing off the demoralization they had.
Both were at the same time in a dermatologist who had prescribed Roacutan, but the endocrine did not advise taking Roacutane at the same time as Metformin (Glucofage). Here came the difference: one of them decided to take the glucofage first to lose weight and the other preferred to treat their acne with Roacutane first.
Today I can tell you that the one who took the Metformin (Glucofage) has 18 kg less and does NOT have acne (impressive how it was improved) is beautiful. My other girl is still chubby, this is worse than before because her sister is now a beauty and she has suffered terrible consequences that are the side effects of Roacutane. Some have been that it has peeled all the face, the lips, has all the skin as scaly, can not take sun for long and also their polycystic ovaries are getting worse.
Metformin though primarily an antidiabetic drug, has found to play an important role in a number of cutaneous disorders. Because of its role in improving hyperinsulinemia, it has proven beneficial in hormonal acne, hidradenitis suppurativa (HS) and acanthosis nigricans. Its antiandrogenic properties further serve as an add-on to the conventional management of hirsutism associated with polycystic ovarian syndrome.
Very recently, systemic usage of metformin for psoriasis and cutaneous malignancies has shown promising results. Interestingly, metformin has also been topically used in hyperpigmentary disorders with pertinent levels of improvement and happens to be the most recent addition to the list of dermatologic indications. Though an oral hypoglycemic agent to begin with, metformin today has proven to be a boon for dermatologists.
(dimethylbiguanide) today is a widely used drug prescribed for diabetic patients. The history of metformin dates back to the usage of the herb Galega officinalis.
This herb was found to be rich in a substance called guanidine with blood-glucose-lowering properties, which later was discovered to be the chemical basis of metformin. Though an antidiabetic drug to begin with, metformin has proven to be a drug of importance, in a number of cutaneous indications. This review will discuss the dermatologic perspective of metformin.
orally, metformin has a bioavailability of 40–60%. Within 6 h of drug intake, gastrointestinal absorption is complete. Gastrointestinal absorption of metformin is mediated by plasma membrane monoamine transporter. Metformin does not undergo any metabolism, and it has a t1/2 of 5 h.
Organic cation transporter (OCT) 1 and OCT3 facilitate hepatic uptake of metformin, whereas OCT2 plays a role in the uptake of metformin from the circulation, to renal epithelial cells. Excretion of metformin occurs by active tubular secretion through the kidneys.
drug has shown efficacy and therapeutic applications in dermatological disorders too. A brief description of these follows:
Acanthosis nigricans (AN) is a common cutaneous condition characterized by dark, coarse and thickened skin with a velvety feel.
It usually is symmetrical in distribution involving the neck, axilla, antecubital and popliteal fossa, groin folds, and rarely other sites such as face, eyelids, umbilical region, knuckles, palms, soles, nipple, and areola. Recently, the association of benign AN with insulin resistance and hyperinsulinemia has been clearly established with obesity being a frequent accompaniment in these patients.
 Further insulin levels in obese AN patients has been found to be significantly higher when compared to obese individuals who do not have AN.
Role of Metformin in Acanthosis Nigricans
The pathomechanics of AN is complex involving an interplay between various receptors and growth factors.[5,6,7] Metformin in AN brings its beneficial effects as depicted in Figure 1. Moreover, combination of metformin with thiozolidones or glimepiride could potentiate the effect of metformin, on AN, in cases not responding to metformin alone